Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors

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ID: 120307
2006
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Abstract
Testosterone supplementation in men decreases fat mass; however, the mechanisms by which it inhibits fat mass are unknown. We hypothesized that testosterone inhibits adipogenic differentiation of preadipocytes by activation of androgen receptor (AR)/beta-catenin interaction and subsequent translocat …
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Authors Singh R;Artaza JN;Taylor WE;Braga M;Yuan X;Gonzalez-Cadavid NF;Bhasin S;;
Journal endocrinology
Year 2006
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16210377
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice RNA animals pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural Adipose Tissue / cytology* 3T3 Cells Adipocytes / drug effects Cell Differentiation / drug effects Receptors Messenger / genetics gene expression regulation / drug effects genetic / drug effects transcription transcription factors / genetics* adipocytes / cytology* signal transduction / physiology testosterone / pharmacology* reverse transcriptase polymerase chain reaction wnt proteins / genetics wnt proteins / physiology* protein transport / drug effects pmid:16210377 pmc4417624 doi:10.1210/en.2004-1649 rajan singh jorge n artaza shalender bhasin cell nucleus / metabolism* androgen / metabolism* tcf transcription factors / metabolism* transcription factor 7-like 2 protein beta catenin / metabolism*

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