1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase

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ID: 120170
2012
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Abstract
α-Fluorinated-1,1-bisphosphonic acids derived from fatty acids were designed, synthesized and biologically evaluated against Trypanosoma cruzi, the etiologic agent of Chagas disease, and against Toxoplasma gondii, the agent responsible for toxoplasmosis, and also towards the target parasitic enzymes …
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Authors Szajnman SH;Rosso VS;Malayil L;Smith A;Moreno SN;Docampo R;Rodriguez JB;;
Journal Organic & biomolecular chemistry
Year 2012
DOI
DOI not found
URL
https://www.pubmed.gov/22215028/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural enzyme inhibitors / pharmacology* diphosphonates / chemistry valeria s rosso sergio h szajnman juan b rodriguez diphosphonates / pharmacology* geranyltranstransferase / antagonists & inhibitors* geranyltranstransferase / metabolism pmid:22215028 pmc3458512 doi:10.1039/c1ob06602a antiprotozoal agents / chemistry antiprotozoal agents / pharmacology* enzyme inhibitors / chemistry toxoplasma / enzymology* toxoplasma / metabolism

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