Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase

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ID: 120019
2011
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Abstract
The effect of long-chain 2-alkylaminoethyl-1,1-bisphosphonates against proliferation of the clinically more relevant form of Trypanosoma cruzi, the etiologic agent of American trypanosomiasis (Chagas' disease), and against tachyzoites of Toxoplasma gondii was investigated. Particularly, compound 26 …
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vs2011bioorganicsynthesis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rosso VS;Szajnman SH;Malayil L;Galizzi M;Moreno SN;Docampo R;Rodriguez JB;;
Journal bioorganic & medicinal chemistry
Year 2011
DOI
DOI not found
URL
https://www.pubmed.gov/21419634/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural Molecular Targeted Therapy enzyme inhibitors / pharmacology chlorocebus aethiops vero cells structure-activity relationship pmid:21419634 pmc3071284 doi:10.1016/j.bmc.2011.02.037 valeria s rosso sergio h szajnman juan b rodriguez antiprotozoal agents / chemical synthesis antiprotozoal agents / chemistry* antiprotozoal agents / pharmacology diphosphonates / chemical synthesis diphosphonates / chemistry* diphosphonates / pharmacology* enzyme inhibitors / chemical synthesis enzyme inhibitors / chemistry* geranyltranstransferase / antagonists & inhibitors* geranyltranstransferase / metabolism toxoplasma / drug effects* toxoplasma / enzymology trypanosoma cruzi / drug effects* trypanosoma cruzi / enzymology

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