RENEWED CATCH-UP GROWTH ON INCREASING GROWTH HORMONE (GH) DOSAGE DURING GH REPLACEMENT THERAPY
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ID: 119853
1970
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Abstract
Sustained accelerated growth is necessary for GH-deficient patients to achieve normal mature heights. However, the catch-up growth seen during the initial 12-18 mos of standard GH replacement Rx (0.3 U/kg/wk) does not persist and few GH-treated children attain their full potential height. Previous studies of the dose/growth-response relationship have been confined to the initial phase of Rx. To assess the efficacy and safety of higher doses, given when catch-up growth had ceased, we gave GH for 8 months at 0.9U/kg/week to 8 GH-deficient children (7-12 yrs) earlier treated for 2-8 yrs with GH at 0.3 U/kg/wk. Mean growth velocity (GV) increased from 5.5±1.2 to 9.7±2.5 cm/yr (p
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| Reference Key |
gertner1970pediatricrenewed
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|---|---|
| Authors | J Gertner;S Gianfredi;W Tamborlane;J Gertner;S Gianfredi;W Tamborlane; |
| Journal | Pediatric research |
| Year | 1970 |
| DOI |
doi:10.1203/00006450-198404001-00447
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