The PI3K Pathway in Human Disease

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ID: 119730
2017
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Abstract
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested in oncology trials, resulting in regulatory approval of one isoform-selectiv …
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Authors Fruman DA;Chiu H;Hopkins BD;Bagrodia S;Cantley LC;Abraham RT;;
Journal Cell
Year 2017
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