Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant

Clicks: 485
ID: 118936
1997
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Abstract
A live, cold-passaged (cp) candidate vaccine virus, designated respiratory syncytial virus (RSV) B1 cp-52/2B5 (cp-52), replicated efficiently in Vero cells, but was found to be overattenuated for RSV-seronegative infants and children. Sequence analysis of reverse-transcription-PCR-amplified fragment …
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Authors Karron RA;Buonagurio DA;Georgiu AF;Whitehead SS;Adamus JE;Clements-Mann ML;Harris DO;Randolph VB;Udem SA;Murphy BR;Sidhu MS;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9391135
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't Child Infant P.H.S. Genes human / genetics* Viral vaccines hn protein* viral envelope proteins chromosome mapping chlorocebus aethiops vero cells respiratory syncytial virus infections / prevention & control respiratory syncytial virus viral proteins / immunology mutation* viral proteins / genetics* viral proteins / physiology* gene deletion human / physiology* r a karron pmid:9391135 pmc28415 doi:10.1073/pnas.94.25.13961 d a buonagurio m s sidhu human / pathogenicity attenuated / genetics synthetic / genetics viral vaccines / genetics virulence / genetics virus replication / genetics

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