Inhibiting the urokinase-type plasminogen activator receptor system recovers STZ-induced diabetic nephropathy

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ID: 118797
2019
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Abstract
The urokinase-type plasminogen activator (uPA) receptor (uPAR) participates to the mechanisms causing renal damage in response to hyperglycaemia. The main function of uPAR in podocytes (as well as soluble uPAR -(s)uPAR- from circulation) is to regulate podocyte function through αvβ3 integrin/Rac-1. …
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Authors Dal Monte M;Cammalleri M;Pecci V;Carmosino M;Procino G;Pini A;De Rosa M;Pavone V;Svelto M;Bagnoli P;;
Journal Journal of cellular and molecular medicine
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/30426662/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male Rats Sprague-Dawley Receptors signal transduction / physiology diabetes mellitus massimo dal monte inflammation / metabolism up-regulation / physiology maurizio cammalleri paola bagnoli pmid:30426662 pmc6349167 doi:10.1111/jcmm.14004 experimental / chemically induced experimental / metabolism* diabetic nephropathies / chemically induced* diabetic nephropathies / metabolism* kidney / metabolism podocytes / metabolism urokinase plasminogen activator / metabolism* streptozocin / pharmacology* urokinase-type plasminogen activator / metabolism

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