Dendritic cell anergy results from endotoxemia in severe malnutrition

Clicks: 296
ID: 118745
2009
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Abstract
Malnutrition predicts an increased risk of morbidity and mortality from infection. Defects in cell-mediated immunity, such as thymic atrophy, impaired cutaneous tuberculin responses, and reduced T cell mitogenesis in vitro, are well characterized. There has been no convincing mechanism proposed for …
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Authors Hughes SM;Amadi B;Mwiya M;Nkamba H;Tomkins A;Goldblatt D;;
Journal journal of immunology (baltimore, md : 1950)
Year 2009
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/19625645
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male Child Infant Comparative Study preschool Cells Cultured severity of illness index Cohort Studies interleukin-12 / deficiency hiv infections / immunology malnutrition / immunology* dendritic cells / immunology* pmid:19625645 doi:10.4049/jimmunol.0803518 stephen miles hughes beatrice amadi david goldblatt coculture techniques dendritic cells / metabolism dendritic cells / pathology* down-regulation / immunology endotoxemia / immunology* endotoxemia / metabolism endotoxemia / pathology* hiv infections / metabolism hiv infections / pathology hla-dr antigens / metabolism interleukin-10 / metabolism malnutrition / metabolism malnutrition / pathology* up-regulation / immunology

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