Ferritin levels predict severe dengue

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ID: 118684
2014
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Abstract
Currently, no tests are available to monitor and predict severity and outcome of dengue. To find potential markers that predict dengue severity, the present study validated the serum level of three acute-phase proteins α-1 antitrypsin, ceruloplasmin and ferritin in a pool of severe dengue cases compared to non-severe forms and other febrile illness controls. A total of 96 patients were divided into two equal groups with group ‘A’ comprising dengue-infected cases and group ‘B’ with other febrile illness cases negative for dengue. Out of 48 dengue-infected cases, 13 had severe dengue and the remaining 35 were classified as non-severe dengue. Immunoassays were performed to evaluate the serum levels of acute-phase proteins both on the day of admission and on the day of defervescence. The efficiency of individual proteins in predicting the disease severity was assessed using receiver operating characteristic curve. The study did not find any significant difference in the levels of α-1 antitrypsin between the clinical groups. A significant increase in the levels of ceruloplasmin around defervescence in severe cases compared to non-severe and other febrile controls was observed and this is the first report describing the potential association of ceruloplasmin and dengue severity. Interestingly, a steady increase in the level of serum ferritin was recorded throughout the course of illness. Among all the three proteins, the elevated ferritin level could predict the disease severity with highest sensitivity and specificity of 76.9 and 83.3 %, respectively, on the day of admission and the same was found to be 90 and 91.6 % around defervescence. On the basis of this diagnostic efficiency, we propose that ferritin may serve as a potential biomarker for an early prediction of disease severity.
Reference Key
soundravally2014infectionferritin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors R. Soundravally;B. Agieshkumar;M. Daisy;J. Sherin;C. C. Cleetus;R. Soundravally;B. Agieshkumar;M. Daisy;J. Sherin;C. C. Cleetus;
Journal Infection
Year 2014
DOI
doi:10.1007/s15010-014-0683-4
URL
http://dx.doi.org/10.1007/s15010-014-0683-4
Keywords
internal medicine infectious diseases general practice / family medicine National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male adolescent middle aged young adult Child preschool sensitivity and specificity case-control studies biomarkers / blood* roc curve ferritins / blood* pmid:25354733 doi:10.1007/s15010-014-0683-4 r soundravally b agieshkumar c c cleetus ceruloplasmin / analysis severe dengue / blood* severe dengue / epidemiology*

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