Functions of PIWI proteins in spermatogenesis

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ID: 118412
2011
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Abstract
Recently, a significant understanding of the molecular mechanisms regulating spermatogenesis has been achieved utilizing small RNA molecules (small RNAs), including small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs) which emerged as important regulators of gene expression at the post-transcriptional or translation level. piRNAs are only present in pachytene spermatocytes and round spermatids, whereas miRNAs are expressed abundantly in male germ cells throughout spermatogenesis. This review is aimed at providing a glimpse of piRNAs and their interacting family proteins such as PIWIL1, PIWIL2, and PIWIL4 in spermatogenesis.
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Authors Chong Won Bak,Tae-Ki Yoon,Youngsok Choi;Chong Won Bak;Tae-Ki Yoon;Youngsok Choi;
Journal clinical and experimental reproductive medicine
Year 2011
DOI
10.5653/cerm.2011.38.2.61
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