Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

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ID: 118199
2020
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Abstract
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.
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zielińska2020moleculespolymeric Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Aleksandra Zielińska;Filipa Carreiró;Ana M. Oliveira;Andreia Neves;Bárbara Pires;D. Nagasamy Venkatesh;Alessandra Durazzo;Massimo Lucarini;Piotr Eder;Amélia M. Silva;Antonello Santini;Eliana B. Souto;Zielińska, Aleksandra;Carreiró, Filipa;Oliveira, Ana M.;Neves, Andreia;Pires, Bárbara;Venkatesh, D. Nagasamy;Durazzo, Alessandra;Lucarini, Massimo;Eder, Piotr;Silva, Amélia M.;Santini, Antonello;Souto, Eliana B.;
Journal molecules
Year 2020
DOI
10.3390/molecules25163731
URL
https://doi.org/10.3390/molecules25163731
Keywords
targeted drug delivery toxicology therapeutic potential nanospheres polymeric nanoparticles nanocapsules ecotoxicology.

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