GSK-3β inhibition confers cardioprotection associated with the restoration of mitochondrial function and suppression of endoplasmic reticulum stress in sevoflurane preconditioned rats following ischemia/reperfusion injury

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ID: 118080
2018
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Abstract
Taken together, the findings obtained from the study support the concept that sevoflurane preconditioning confers cardioprotection against myocardial I/R injury and GSK-3β/β-catenin signaling activation mediated by TDZD-8 as a novel target to prolong cardioprotection by sevoflurane anaesthesia.
Reference Key
y2018perfusiongsk-3β Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang Y;Ge C;Chen J;Tang K;Liu J;;
Journal perfusion
Year 2018
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/29987974
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine Cardiotonic Agents / pharmacology* Glycogen Synthase Kinase 3 beta / metabolism Rats Sprague-Dawley enzyme inhibitors / pharmacology* signal transduction / drug effects* mitochondria myocardium / pathology pmid:29987974 doi:10.1177/0267659118787143 yujia wang chunlin ge jianjun liu endoplasmic reticulum stress / drug effects glycogen synthase kinase 3 beta / antagonists & inhibitors* heart / enzymology* heart / pathology myocardial reperfusion injury / drug therapy* myocardial reperfusion injury / enzymology myocardial reperfusion injury / pathology myocardium / enzymology sevoflurane / pharmacology* thiadiazoles / pharmacology* beta catenin / metabolism

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