Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys

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ID: 118001
1994
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Abstract
The antidiabetic effects of pioglitazone hydrochloride were evaluated in 6 spontaneously obese, insulin-resistant rhesus monkeys. The animals were studied during six successive 2-wk treatment phases separated by 2-wk rest periods: two placebo phases; 0.3, 1.0, and 3.0 mg.kg-1 x day-1 pioglitazone hy …
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Authors Kemnitz JW;Elson DF;Roecker EB;Baum ST;Bergman RN;Meglasson MD;;
Journal Diabetes
Year 1994
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8288044
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female male P.H.S. Insulin / pharmacology* macaca mulatta body weight / drug effects glucose tolerance test insulin / blood* insulin resistance / physiology* pioglitazone j w kemnitz blood glucose / metabolism* fasting eating thiazolidinediones* pmid:8288044 doi:10.2337/diab.43.2.204 d f elson m d meglasson blood glucose / drug effects blood pressure / drug effects* feeding behavior / drug effects heart rate / drug effects hypoglycemic agents / pharmacology* obesity / blood obesity / physiopathology* thiazoles / pharmacology* tolbutamide / pharmacology triglycerides / blood*

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