Zebrafish hox Clusters and Vertebrate Genome Evolution

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ID: 117873
1998
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Abstract
HOX genes specify cell fate in the anterior-posterior axis of animal embryos. Invertebrate chordates have one HOX cluster, but mammals have four, suggesting that cluster duplication facilitated the evolution of vertebrate body plans. This report shows that zebrafish have seven hox clusters. Phylogenetic analysis and genetic mapping suggest a chromosome doubling event, probably by whole genome duplication, after the divergence of ray-finned and lobe-finned fishes but before the teleost radiation. Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis.
Reference Key
amores1998sciencezebrafish Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Angel Amores;Allan Force;Yi-Lin Yan;Lucille Joly;Chris Amemiya;Andreas Fritz;Robert K. Ho;James Langeland;Victoria Prince;Yan-Ling Wang;Monte Westerfield;Marc Ekker;John H. Postlethwait;Angel Amores;Allan Force;Yi-Lin Yan;Lucille Joly;Chris Amemiya;Andreas Fritz;Robert K. Ho;James Langeland;Victoria Prince;Yan-Ling Wang;Monte Westerfield;Marc Ekker;John H. Postlethwait;
Journal Science
Year 1998
DOI
10.1126/science.282.5394.1711
URL
https://doi.org/10.1126%2Fscience.282.5394.1711
Keywords
Evolution National Center for Biotechnology Information NCBI NLM MEDLINE genetic animals pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't non-p.h.s. P.H.S. Molecular* Genes Phylogeny chromosome mapping zebrafish / genetics* genome* multigene family* gene duplication homeobox* pmid:9831563 doi:10.1126/science.282.5394.1711 a amores a force j h postlethwait chromosomes / genetics pseudogenes

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