Nonhuman primate models of polycystic ovary syndrome

Clicks: 357
ID: 117828
2013
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Abstract
With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PC …
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Authors Abbott DH;Nicol LE;Levine JE;Xu N;Goodarzi MO;Dumesic DA;;
Journal molecular and cellular endocrinology
Year 2013
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/23370180
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE review animals humans pubmed abstract nih national institutes of health national library of medicine pregnancy research support non-u.s. gov't female N.I.H. Extramural Disease Models david h abbott daniel a dumesic age factors animal* newborn phenotype Polycystic Ovary Syndrome / metabolism* polycystic ovary syndrome / embryology pmid:23370180 pmc3683573 doi:10.1016/j.mce.2013.01.013 lindsey e nicol insulin resistance primates testosterone / physiology

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