The Transcriptome of the Sea Urchin Embryo

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ID: 117647
2006
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Abstract
The sea urchin Strongylocentrotus purpuratus is a model organism for study of the genomic control circuitry underlying embryonic development. We examined the complete repertoire of genes expressed in the S. purpuratus embryo, up to late gastrula stage, by means of high-resolution custom tiling arrays covering the whole genome. We detected complete spliced structures even for genes known to be expressed at low levels in only a few cells. At least 11,000 to 12,000 genes are used in embryogenesis. These include most of the genes encoding transcription factors and signaling proteins, as well as some classes of general cytoskeletal and metabolic proteins, but only a minor fraction of genes encoding immune functions and sensory receptors. Thousands of small asymmetric transcripts of unknown function were also detected in intergenic regions throughout the genome. The tiling array data were used to correct and authenticate several thousand gene models during the genome annotation process.
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samanta2006sciencethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Manoj P. Samanta;Waraporn Tongprasit;Sorin Istrail;R. Andrew Cameron;Qiang Tu;Eric H. Davidson;Viktor Stolc;Manoj P. Samanta;Waraporn Tongprasit;Sorin Istrail;R. Andrew Cameron;Qiang Tu;Eric H. Davidson;Viktor Stolc;
Journal Science
Year 2006
DOI
10.1126/science.1131898
URL
http://dx.doi.org/10.1126%2Fscience.1131898
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. N.I.H. Extramural genetic* Messenger / genetics transcription messenger / metabolism transcription factors / metabolism gene expression profiling computational biology oligonucleotide array sequence analysis embryo developmental* nucleic acid hybridization signal transduction / genetics transcription factors / genetics genome* pmid:17095694 doi:10.1126/science.1131898 manoj p samanta waraporn tongprasit viktor stolc blastula / metabolism nonmammalian / metabolism* embryonic development / genetics* gastrula / metabolism intracellular signaling peptides and proteins / genetics intracellular signaling peptides and proteins / metabolism molecular probe techniques untranslated / genetics untranslated / metabolism strongylocentrotus purpuratus / embryology* strongylocentrotus purpuratus / genetics* strongylocentrotus purpuratus / growth & development

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