Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen

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ID: 117496
2010
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Abstract
The ability of the thymus to generate a population of T cells that is, for the most part, self-restricted and self-tolerant depends to a great extent on the Ags encountered during differentiation. We recently showed that mycobacteria disseminate to the thymus, which raised the questions of how mycob …
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Authors Nobrega C;Roque S;Nunes-Alves C;Coelho A;Medeiros I;Castro AG;Appelberg R;Correia-Neves M;;
Journal journal of immunology (baltimore, md : 1950)
Year 2010
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/19949112
Keywords
image processing National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female fluorescent antibody technique nude computer-assisted flow cytometry t-lymphocytes / immunology* immune tolerance / immunology* tuberculosis / immunology* pmid:19949112 doi:10.4049/jimmunol.0902152 claudia nobrega susana roque margarida correia-neves cell differentiation / immunology mycobacterium avium / immunology t-lymphocytes / cytology thymus gland / immunology thymus gland / microbiology* tuberculosis / veterinary

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