The compound 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via reactive oxygen species-regulated mitogen-activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells

Clicks: 326
ID: 117244
2018
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Abstract
Hit, Lead & Candidate Discovery It is reported that 1,4-naphthoquinones and their derivatives have potent antitumor activity in various cancers, although their clinical application is limited by observed side effects. To improve the therapeutic efficacy of naphthoquinones in the treatment of can …
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Authors Wang JR;Shen GN;Luo YH;Piao XJ;Shen M;Liu C;Wang Y;Meng LQ;Zhang Y;Wang H;Li JQ;Xu WT;Liu Y;Sun HN;Han YH;Jin MH;Cao LK;Jin CH;;
Journal drug development research
Year 2018
DOI
DOI not found
URL
https://www.pubmed.gov/30222185/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Cells Cultured apoptosis / drug effects* stomach neoplasms / metabolism reactive oxygen species cheng-hao jin stat3 transcription factor / metabolism pmid:30222185 doi:10.1002/ddr.21442 jia-ru wang gui-nan shen 1-naphthylamine / administration & dosage 1-naphthylamine / adverse effects 1-naphthylamine / analogs & derivatives* 1-naphthylamine / chemical synthesis map kinase signaling system stomach neoplasms / drug therapy* stomach neoplasms / pathology

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