Human peripheral blood mononuclear cells require factor X and platelets for expression of prothrombinase activity in response to bacterial lipopolysaccharide

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ID: 117097
1970
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Abstract
We investigated whether human peripheral blood mononuclear cells (PBMC) express prothrombinase following stimulation with bacterial lipopolysaccharide (LPS). LPS-stimulated PBMC devoid of contaminating platelets failed to activate prothrombin directly. Addition of platelets did not result in expression of prothrombinase in the absence of factor X whereas the combination of platelets and factor X resulted in strong prothrombinase activity on LPS-activated cells. The induced prothrombinase was dependent on tissue factor, as the activity was completely inhibited by an anti-tissue factor antibody. Our data suggest that platelet/monocyte cooperation is important in the generation of prothrombinase activity in response to endotoxin.
Reference Key
pejler1970annalshuman Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors G. Pejler;C. Geczy;G. Pejler;C. Geczy;
Journal Annals of hematology
Year 1970
DOI
doi:10.1007/s002770100288
URL
https://link.springer.com/article/10.1007/s002770100288
Keywords
oncology hematology

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