Alginate Hydrogel-Embedded Capillary Sensor for Quantitative Immunoassay with Naked Eye

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ID: 117044
2020
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Abstract
We have developed an alginate hydrogel-embedded capillary sensor (AHCS) for naked eye-based quantification of immunoassay. Alkaline phosphatase (ALP) can modulate gel-sol transformation to increase the permeability of Cu2+-cross-linked alginate hydrogel film in the AHCS, followed by solution exchange into the capillary. Through measuring the length of the liquid phase of the microfluidics in the capillary at a given time, the concentration of the ALP could be quantified with the naked eye. Since ALP is widely applied as a signal reporter for immunoassays, the AHCS could easily accommodate conventional immune sensing platforms. We justify the practicality of AHCS with hepatitis B virus surface antigen (HBsAg) in serum samples and got comparable results with commercialized immunoassay. This AHCS is easy to make and use, effective in cost, and robust in quantification with the naked eye, showing great promise for next generation point-of-care testing.
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zheng2020sensorsalginate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wenshu Zheng;Cen Gao;Liheng Shen;Chang Qu;Xuan Zhang;Lu Yang;Qiang Feng;Rongbing Tang;Zheng, Wenshu;Gao, Cen;Shen, Liheng;Qu, Chang;Zhang, Xuan;Yang, Lu;Feng, Qiang;Tang, Rongbing;
Journal sensors
Year 2020
DOI
10.3390/s20174831
URL
https://www.mdpi.com/1424-8220/20/17/4831
Keywords
immunoassay poct alginate hydrogel capillary microfluidics

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