Forming functional fat: a growing understanding of adipocyte differentiation

Clicks: 246
ID: 116997
2011
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Abstract
The differentiation of adipocytes from mesenchymal stem cells, known as adipogenesis, occurs in two stages, commitment and terminal differentiation, both of which are tightly regulated by mechanical and molecular cues. A better understanding of the underlying mechanisms may identify therapeutic targets for metabolic diseases.
Reference Key
cristancho2011natureforming Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ana G. Cristancho;Mitchell A. Lazar;Ana G. Cristancho;Mitchell A. Lazar;
Journal nature reviews molecular cell biology
Year 2011
DOI
doi:10.1038/nrm3198
URL
http://dx.doi.org/10.1038/nrm3198
Keywords
gene expression development metabolism metabolic diseases epigenomics cell signalling fats National Center for Biotechnology Information NCBI NLM MEDLINE genetic review animals humans pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't N.I.H. Extramural Adipocytes / physiology* Transforming Growth Factor beta / physiology mesenchymal stem cells / cytology adipocytes / cytology* biological cell differentiation / physiology signal transduction cell differentiation / genetics epigenesis ppar gamma / genetics adipogenesis / physiology* pmid:21952300 pmc7171550 doi:10.1038/nrm3198 ana g cristancho mitchell a lazar adipogenesis / genetics ccaat-enhancer-binding proteins / physiology cell lineage cell shape extracellular matrix / physiology mesenchymal stem cells / physiology ppar gamma / physiology wnt signaling pathway rho gtp-binding proteins / physiology

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