Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol

Clicks: 373
ID: 116962
2011
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Abstract
Hemophagocytic lymphohistiocytosis (HLH) used to have a dismal prognosis. We report the final results of HLH-94, the largest prospective diagnostic/therapeutic HLH study so far. The treatment includes immunosuppressive and cytotoxic therapy aiming at clinical remission, followed by HSCT in patients …
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Authors Trottestam H;Horne A;Aricò M;Egeler RM;Filipovich AH;Gadner H;Imashuku S;Ladisch S;Webb D;Janka G;Henter JI; ;;
Journal Blood
Year 2011
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/21900192
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male adolescent Child Infant Immunosuppressive Agents / administration & dosage* Immunosuppressive Agents / adverse effects newborn preschool Clinical Trial follow-up studies Survival Analysis time factors drug combinations combined modality therapy lymphohistiocytosis hemophagocytic / diagnosis maintenance chemotherapy hemophagocytic / drug therapy* immunotherapy / methods pmid:21900192 pmc3208276 doi:10.1182/blood-2011-06-356261 helena trottestam annacarin horne histiocyte society clinical protocols cytotoxins / administration & dosage* cytotoxins / adverse effects hematopoietic stem cell transplantation immunotherapy / adverse effects hemophagocytic / mortality hemophagocytic / therapy

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