Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells

Clicks: 400
ID: 116906
1997
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Abstract
Treatment of human cells with 2',5' oligoadenylate covalently linked to antisense (2-5A-antisense) results in the selective cleavage of targeted RNA species by 2-5A-dependent RNase L. Here we show that 2-5A-antisense containing stabilizing modifications at both termini are effective in suppressing t …
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Authors Cirino NM;Li G;Xiao W;Torrence PF;Silverman RH;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9050883
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. cell line polymerase chain reaction n m cirino electrophoresis agar gel respiratory syncytial viruses / drug effects* antiviral agents / pharmacology* respiratory syncytial viruses / physiology viral / metabolism* virus replication / drug effects binding sites respiratory syncytial viruses / metabolism pmid:9050883 pmc20021 doi:10.1073/pnas.94.5.1937 g li r h silverman adenine nucleotides / genetics adenine nucleotides / pharmacology* endoribonucleases / metabolism nucleic acid conformation oligonucleotides / genetics oligoribonucleotides / genetics oligoribonucleotides / pharmacology* antisense / genetics antisense / pharmacology* messenger / metabolism* viral proteins / metabolism

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