Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children

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ID: 116752
1997
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Abstract
Two live-attenuated, cold-passaged (cp), temperature-sensitive (ts) candidate vaccines, designated cpts530/1009 and cpts248/955, were attenuated, genetically stable, and immunogenic in chimpanzees and were highly attenuated for human adults. In respiratory syncytial virus (RSV)-seropositive children …
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Authors Karron RA;Wright PF;Crowe JE;Clements-Mann ML;Thompson J;Makhene M;Casey R;Murphy BR;;
Journal The Journal of infectious diseases
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9395351
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't adult female male adolescent middle aged Child Infant P.H.S. preschool Clinical Trial Randomized Controlled Trial Antibodies Double-Blind Method cell line Viral / analysis mutation respiratory syncytial viruses / immunology* viral / blood vaccines attenuated / immunology b r murphy respiratory syncytial virus infections / immunology* viral / biosynthesis* respiratory syncytial viruses / genetics respiratory syncytial viruses / pathogenicity mutagenesis viral vaccines / immunology* pmid:9395351 doi:10.1086/514138 r a karron p f wright fluorouracil nasal lavage fluid / immunology nasal lavage fluid / virology pan troglodytes respiratory syncytial virus infections / transmission

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