Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes

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ID: 116746
2019
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Abstract
The present study investigated the mechanisms of apoptosis induced by cryptotanshinone (CT) in human rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLSs). Cell Counting kit‑8 assay was performed to determine the cytotoxic effects of CT in human RA‑FLSs, including primary RA‑FLS, HFLS‑RA and M …
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Authors Sun HN;Luo YH;Meng LQ;Piao XJ;Wang Y;Wang JR;Wang H;Zhang Y;Li JQ;Xu WT;Liu Y;Zhang Y;Zhang T;Han YH;Jin MH;Shen GN;Zang YQ;Cao LK;Zhang DJ;Jin CH;;
Journal international journal of molecular medicine
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/30535477/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine Proto-Oncogene Proteins c-akt / metabolism cell line Fibroblasts / metabolism arthritis biomarkers hu-nan sun apoptosis / drug effects* reactive oxygen species / metabolism* cell survival / drug effects ying-hua luo cheng-hao jin cell proliferation / drug effects mitochondria / drug effects pmid:30535477 doi:10.3892/ijmm.2018.4012 rheumatoid / metabolism* cell cycle / drug effects mitochondria / metabolism phenanthrenes / pharmacology* stat3 transcription factor / metabolism synoviocytes / drug effects* synoviocytes / metabolism*

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