Culture and Real-time Polymerase Chain reaction sensitivity in the diagnosis of invasive meningococcal disease: Does culture miss less severe cases?

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ID: 116714
2019
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Abstract
In conclusion our study demonstrated that qPCR is significantly (at least 3 times) more sensitive than culture in the laboratory confirmation of IMD. The study also demonstrated that culture negativity is not associated with lower bacterial loads and with less severe cases. On the other side, in pat …
Reference Key
s2019plosculture Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Guiducci S;Moriondo M;Nieddu F;Ricci S;De Vitis E;Casini A;Poggi GM;Indolfi G;Resti M;Azzari C;;
Journal PloS one
Year 2019
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/30865671
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male adolescent young adult Child Infant Comparative Study newborn preschool Retrospective Studies DNA sensitivity and specificity sepsis / mortality severity of illness index meningitis false negative reactions neisseria meningitidis / isolation & purification* sepsis / microbiology neisseria meningitidis / genetics bacterial / isolation & purification meningococcal / microbiology pmid:30865671 pmc6415896 doi:10.1371/journal.pone.0212922 sara guiducci maria moriondo chiara azzari bacterial load / methods* cell culture techniques / statistics & numerical data meningococcal / diagnosis* meningococcal / mortality real-time polymerase chain reaction / statistics & numerical data sepsis / diagnosis* meningitis antibiotics cerebrospinal fluid blood sepsis meningococcal disease neisseria meningitidis bacterial pathogens

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