Decrease of Normotest/Thrombotest discrepancy in non-contacted coumarin plasma after glass or ellagic acid activation
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ID: 116549
1970
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Abstract
Activation of coumarin plasmas in glass tubes for 60 min resulted in a clear shortening of Thrombotest clotting times. Normotest clotting times were shortened too but to a much lesser extent. As a consequence the Normotest (NT)/Thrombotest (TT) discrepancy which was quite large at 0 time, became progressively smaller. This phenomenon was observed both in undiluted and 6∶10 diluted plasma. After ellagic acid activation a similar phenomenon was noted even though a less pronounced shortening of Thrombotest was noted. These data suggest that Thrombotest is very sensitive to contact phase and to factor VII activation and not to any coumarin-induced inhibitors.
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| Authors | Antonio Girolami;Giovanni Patrassi;Alessandro Burul;Antonio Girolami;Giovanni Patrassi;Alessandro Burul; |
| Journal | blut |
| Year | 1970 |
| DOI |
doi:10.1007/BF01005211
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