CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells

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ID: 116546
1992
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Abstract
Respiratory syncytial (RS) virus-specific T cell lines were derived from the spleens of BALB/c mice primed by intranasal infection with RS virus. The lines were expanded by repeated antigenic stimulation in vitro, and separated into CD4+ and CD8+ T cell-enriched fractions by immunomagnetic adhesion. …
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Authors Alwan WH;Record FM;Openshaw PJ;;
Journal clinical and experimental immunology
Year 1992
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/1351433
Keywords
immunity National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female Comparative Study P.H.S. cell line Inbred BALB C immunotherapy bronchoalveolar lavage fluid / immunology dose-response relationship cellular flow cytometry respirovirus infections / immunology* respirovirus infections / therapy p j openshaw respiratory syncytial viruses* cytotoxicity immunologic t-lymphocyte subsets / immunology* cd4-positive t-lymphocytes / immunology cd8 antigens / immunology* pmid:1351433 pmc1554527 doi:10.1111/j.1365-2249.1992.tb06482.x w h alwan f m record adoptive interleukins / analysis weight loss

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