Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors

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ID: 116201
2008
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Abstract
Protein energy malnutrition (PEM) increases the incidence and severity of infection, causing morbidity and mortality in malnourished populations. Viral-specific cells are an important component of protective immunity. We hypothesized that reduction in the expansion of viral-specific cells and the mi …
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Authors Chatraw JH;Wherry EJ;Ahmed R;Kapasi ZF;;
Journal the journal of nutrition
Year 2008
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/18356339
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support female N.I.H. Extramural Protein-Energy Malnutrition / immunology* Body Weight time factors transgenic eating janel hart chatraw zoher f kapasi cd8-positive t-lymphocytes / immunology* epitopes glycoproteins / immunology pmid:18356339 doi:10.1093/jn/138.4.806 e john wherry arenaviridae infections / immunology* arenaviridae infections / virology cd8-positive t-lymphocytes / cytology* lymphocytic choriomeningitis virus / immunology* stem cells / cytology* stem cells / immunology* substrate specificity

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