Do Bioreactor Designs with More Efficient Oxygen Supply to Ovarian Cortical Tissue Fragments Enhance Follicle Viability and Growth In Vitro?

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ID: 116200
2019
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Abstract
Background: Autotransplantation of cryopreserved ovarian tissue is currently the main option to preserve fertility for cancer patients. To avoid cancer cell reintroduction at transplantation, a multi-step culture system has been proposed to obtain fully competent oocytes for in vitro fertilization. Current in vitro systems are limited by the low number and health of secondary follicles produced during the first step culture of ovarian tissue fragments. To overcome such limitations, bioreactor designs have been proposed to enhance oxygen supply to the tissue, with inconsistent results. This retrospective study investigates, on theoretical grounds, whether the lack of a rational design of the proposed bioreactors prevented the full exploitation of follicle growth potential. Methods: Models describing oxygen transport in bioreactors and tissue were developed and used to predict oxygen availability inside ovarian tissue in the pertinent literature. Results: The proposed theoretical analysis suggests that a successful outcome is associated with enhanced oxygen availability in the cultured tissue in the considered bioreactor designs. This suggests that a rational approach to bioreactor design for ovarian tissue culture in vitro may help exploit tissue potential to support follicle growth.
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catapano2019processesdo Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gerardo Catapano;Gionata Fragomeni;Giuseppe Falvo D’Urso Labate;Luigi De Napoli;Vincenza Barbato;Maddalena Di Nardo;Valentina Costanzo;Teresa Capriglione;Roberto Gualtieri;Riccardo Talevi;Catapano, Gerardo;Fragomeni, Gionata;Falvo D’Urso Labate, Giuseppe;De Napoli, Luigi;Barbato, Vincenza;Di Nardo, Maddalena;Costanzo, Valentina;Capriglione, Teresa;Gualtieri, Roberto;Talevi, Riccardo;
Journal processes
Year 2019
DOI
10.3390/pr7070450
URL
https://doi.org/10.3390/pr7070450
Keywords
transport design bioreactor oxygen in vitro culture ovarian tissue

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