Stunting Is Characterized by Chronic Inflammation in Zimbabwean Infants

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ID: 115929
2014
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Abstract
Background Stunting affects one-third of children in developing countries, but the causes remain unclear. We hypothesized that enteropathy leads to low-grade inflammation, which suppresses the growth hormone-IGF axis and mediates stunting. Methods We conducted a case-control study of 202 HIV-unexposed Zimbabwean infants who were stunted (height-for-age Z-score (HAZ) −0.5; controls) at 18 months. We measured biomarkers of intestinal damage (I-FABP), inflammation (CRP, AGP, IL-6) and growth hormone-IGF axis (IGF-1, IGFBP3) in infant plasma at 6 weeks and 3, 6, 12 and 18 months, and in paired maternal-infant plasma at birth. Adjusted mean differences between biomarkers were estimated using regression models. Multivariate odds ratios of stunting were estimated by logistic regression. Results At birth, cases were shorter (median (IQR) HAZ −1.00 (−1.53, −0.08) vs 0.03 (−0.57, 0.62,); P
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prendergast2014plosstunting Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Andrew J. Prendergast;Sandra Rukobo;Bernard Chasekwa;Kuda Mutasa;Robert Ntozini;Mduduzi N. N. Mbuya;Andrew Jones;Lawrence H. Moulton;Rebecca J. Stoltzfus;Jean H. Humphrey;
Journal PloS one
Year 2014
DOI
10.1371/journal.pone.0086928
URL
https://dx.doi.org/10.1371%2Fjournal.pone.0086928
Keywords
inflammation gastrointestinal tract infants birth weight biomarkers birth c-reactive proteins enteropathies

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