Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene.

Clicks: 271
ID: 11586
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #103 of 189 articles by views in international journal of nanomedicine

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 189 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Here, we fabricated two plasmonic 2D TiCT-based nanocomposites (Au/MXene and Au/FeO/MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure MXene. Au/MXene was synthesized by in situ reduction of tetrachloroauric acid using NaBH on TiCT flakes. For targeted PTT, magnetic Au/FeO/MXene was synthesized via a reaction between freshly prepared magnetite FeO NPs and MXene solution, followed by in situ integration of gold nanoparticles (AuNPs). Morphological characterization by XRD, SEM, and TEM revealed the successful synthesis of Au/MXene and Au/FeO/MXene. Both new composites exhibited a significant in vitro dose-dependent PTT effect against human breast cancer cells MCF7. Interestingly, in vivo acute toxicity assays using zebrafish embryos indicated that Au/MXene and Au/FeO/MXene had less embryonic mortality (LC ≫ 1000 µg/mL) than pure MXene (LC=257.46 µg/mL). Our new Au/MXene and Au/FeO/MXene nanocomposites could be safer and more suitable than the pure MXene for biomedical applications, especially when targeted PTT is warranted.
Reference Key
hussein2019plasmonicinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hussein, Essraa A;Zagho, Moustafa M;Rizeq, Balsam R;Younes, Nadin N;Pintus, Gianfranco;Mahmoud, Khaled A;Nasrallah, Gheyath K;Elzatahry, Ahmed A;
Journal international journal of nanomedicine
Year 2019
DOI
10.2147/IJN.S202208
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.