Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy

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ID: 115729
2016
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Abstract
While immunosuppression is the major determinant of poor outcomes during ART, baseline inflammation is an additional important factor, identifying a subgroup of young children with similar mortality. Antiinflammatory interventions may help improve outcomes.
Reference Key
aj2016thebaseline Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Prendergast AJ;Szubert AJ;Berejena C;Pimundu G;Pala P;Shonhai A;Musiime V;Bwakura-Dangarembizi M;Poulsom H;Hunter P;Musoke P;Kihembo M;Munderi P;Gibb DM;Spyer M;Walker AS;Klein N; ;;
Journal The Journal of infectious diseases
Year 2016
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/27190179
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Africa humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male Child preschool Survival Analysis biomarkers / blood* c-reactive protein / analysis interleukin-6 / blood longitudinal studies cd4 lymphocyte count viral load andrew j prendergast anti-retroviral agents / therapeutic use* hiv infections / drug therapy* hiv infections / mortality pmid:27190179 pmc4918830 doi:10.1093/infdis/jiw148 alexander j szubert arrow trial team hiv / isolation & purification hiv infections / pathology* inflammation / pathology* lipopolysaccharide receptors / blood tumor necrosis factor-alpha / blood

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