Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy

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ID: 115729
2016
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Abstract
While immunosuppression is the major determinant of poor outcomes during ART, baseline inflammation is an additional important factor, identifying a subgroup of young children with similar mortality. Antiinflammatory interventions may help improve outcomes.
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Authors Prendergast AJ;Szubert AJ;Berejena C;Pimundu G;Pala P;Shonhai A;Musiime V;Bwakura-Dangarembizi M;Poulsom H;Hunter P;Musoke P;Kihembo M;Munderi P;Gibb DM;Spyer M;Walker AS;Klein N; ;;
Journal The Journal of infectious diseases
Year 2016
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/27190179
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Africa humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male Child preschool Survival Analysis biomarkers / blood* c-reactive protein / analysis interleukin-6 / blood longitudinal studies cd4 lymphocyte count viral load andrew j prendergast anti-retroviral agents / therapeutic use* hiv infections / drug therapy* hiv infections / mortality pmid:27190179 pmc4918830 doi:10.1093/infdis/jiw148 alexander j szubert arrow trial team hiv / isolation & purification hiv infections / pathology* inflammation / pathology* lipopolysaccharide receptors / blood tumor necrosis factor-alpha / blood

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