The role of TH1 and TH2 cells in a rodent malaria infection

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ID: 115053
1993
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Abstract
CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.
Reference Key
taylor-robinson1993sciencethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors AW Taylor-Robinson;RS Phillips;A Severn;S Moncada;FY Liew;AW Taylor-Robinson;RS Phillips;A Severn;S Moncada;FY Liew;
Journal Science
Year 1993
DOI
10.1126/science.8100366
URL
http://dx.doi.org/10.1126/science.8100366
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Antibodies cell line malaria / immunology* t-lymphocyte subsets / immunology* lymphocyte depletion inbred strains pmid:8100366 doi:10.1126/science.8100366 a w taylor-robinson r s phillips f y liew protozoan / biosynthesis arginine / analogs & derivatives arginine / pharmacology cd4-positive t-lymphocytes / immunology* immunoglobulin g / biosynthesis* nitrates / blood nitric oxide / metabolism* plasmodium chabaudi / immunology* omega-n-methylarginine

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