Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization

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ID: 114934
2007
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Abstract
Sea anemones are seemingly primitive animals that, along with corals, jellyfish, and hydras, constitute the oldest eumetazoan phylum, the Cnidaria. Here, we report a comparative analysis of the draft genome of an emerging cnidarian model, the starlet sea anemone Nematostella vectensis . The sea anemone genome is complex, with a gene repertoire, exon-intron structure, and large-scale gene linkage more similar to vertebrates than to flies or nematodes, implying that the genome of the eumetazoan ancestor was similarly complex. Nearly one-fifth of the inferred genes of the ancestor are eumetazoan novelties, which are enriched for animal functions like cell signaling, adhesion, and synaptic transmission. Analysis of diverse pathways suggests that these gene “inventions” along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor.
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Authors Nicholas H. Putnam;Mansi Srivastava;Uffe Hellsten;Bill Dirks;Jarrod Chapman;Asaf Salamov;Astrid Terry;Harris Shapiro;Erika Lindquist;Vladimir V. Kapitonov;Jerzy Jurka;Grigory Genikhovich;Igor V. Grigoriev;Susan M. Lucas;Robert E. Steele;John R. Finnerty;Ulrich Technau;Mark Q. Martindale;Daniel S. Rokhsar;Nicholas H. Putnam;Mansi Srivastava;Uffe Hellsten;Bill Dirks;Jarrod Chapman;Asaf Salamov;Astrid Terry;Harris Shapiro;Erika Lindquist;Vladimir V. Kapitonov;Jerzy Jurka;Grigory Genikhovich;Igor V. Grigoriev;Susan M. Lucas;Robert E. Steele;John R. Finnerty;Ulrich Technau;Mark Q. Martindale;Daniel S. Rokhsar;
Journal Science
Year 2007
DOI
10.1126/science.1139158
URL
http://dx.doi.org/10.1126%2Fscience.1139158
Keywords
Evolution National Center for Biotechnology Information NCBI NLM MEDLINE Molecular animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. N.I.H. Extramural Comparative Study DNA Genes Sequence Analysis genome human metabolic networks and pathways Phylogeny genomics cell adhesion signal transduction genome* multigene family biological evolution* mansi srivastava daniel s rokhsar synteny muscles / physiology pmid:17615350 doi:10.1126/science.1139158 nicholas h putnam genetic linkage introns nervous system physiological phenomena sea anemones / genetics* sea anemones / metabolism

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