Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies

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1992
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Abstract
It was previously demonstrated that the vaccinia virus recombinants expressing the respiratory syncytial virus (RSV) F, G, or M2 (also designated as 22K) protein (Vac-F, Vac-G, or Vac-M2, respectively) induced almost complete resistance to RSV challenge in BALB/c mice. In the present study, we sough …
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Authors Connors M;Kulkarni AB;Collins PL;Firestone CY;Holmes KL;Morse HC;Murphy BR;;
Journal Journal of Virology
Year 1992
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/1731105
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice animals humans pubmed abstract nih national institutes of health national library of medicine female Antibodies Antigens cell line recombination Inbred BALB C respiratory syncytial viruses / immunology* respirovirus infections / immunology b r murphy hn protein* vaccinia virus / genetics viral envelope proteins viral proteins* viral vaccines* viral / immunology* m connors respiratory syncytial viruses / genetics respirovirus infections / prevention & control t-lymphocyte subsets / immunology* viral / genetics pmid:1731105 pmc240842 doi:10.1128/jvi.66.2.1277-1281.1992 a b kulkarni cd4 antigens / immunology cd4-cd8 ratio cd8 antigens / immunology* immunization* lymphocyte depletion vaccinia virus / immunology*

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