A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

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ID: 114689
2007
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Abstract
Histone modifications induced by activated signalling cascades are crucial to cell-lineage decisions. Osteoblast and adipocyte differentiation from common mesenchymal stem cells is under transcriptional control by numerous factors. Although PPAR-gamma (peroxisome proliferator activated receptor-gamm …
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Authors Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S
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Journal Nature Cell Biology
Year 2007
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/17952062
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Cells Cultured plasmids mutation adipogenesis signal transduction / drug effects genetic vectors transgenic retracted publication phosphorylation pmid:17952062 doi:10.1038/ncb1647 ichiro takada masatomo mihara shigeaki kato core binding factor alpha 1 subunit / metabolism down-regulation histone-lysine n-methyltransferase / drug effects histone-lysine n-methyltransferase / metabolism* osteogenesis ppar gamma / drug effects ppar gamma / genetics ppar gamma / metabolism* signal transduction / physiology* transcriptional activation / physiology* wnt proteins / genetics wnt proteins / pharmacology wnt proteins / physiology* wnt-5a protein

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