A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

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ID: 114689
2007
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Abstract
Histone modifications induced by activated signalling cascades are crucial to cell-lineage decisions. Osteoblast and adipocyte differentiation from common mesenchymal stem cells is under transcriptional control by numerous factors. Although PPAR-gamma (peroxisome proliferator activated receptor-gamm …
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Authors Takada I;Mihara M;Suzawa M;Ohtake F;Kobayashi S;Igarashi M;Youn MY;Takeyama K;Nakamura T;Mezaki Y;Takezawa S;Yogiashi Y;Kitagawa H;Yamada G;Takada S;Minami Y;Shibuya H;Matsumoto K;Kato S;;
Journal Nature Cell Biology
Year 2007
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/17952062
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Cells Cultured plasmids mutation adipogenesis signal transduction / drug effects genetic vectors transgenic retracted publication phosphorylation pmid:17952062 doi:10.1038/ncb1647 ichiro takada masatomo mihara shigeaki kato core binding factor alpha 1 subunit / metabolism down-regulation histone-lysine n-methyltransferase / drug effects histone-lysine n-methyltransferase / metabolism* osteogenesis ppar gamma / drug effects ppar gamma / genetics ppar gamma / metabolism* signal transduction / physiology* transcriptional activation / physiology* wnt proteins / genetics wnt proteins / pharmacology wnt proteins / physiology* wnt-5a protein

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