Evidence for monoclonal proliferation in prolymphocytic leukemia of T- cell origin
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ID: 114419
1970
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Abstract
B- and T-cell markers were studied in a patient with prolymphocytic leukemia, a rare variant of chronic lymphocytic leukemia. Thymus-derived features were identified on the membrane of the neoplastic lymphocytes using the following cellsurface markers: Heterologous T-cell antigen, sheep erythrocyte receptor, surface immunoglobulin, complement receptor, Fc receptor and mouse erythrocyte receptor. Cytogenetic studies of leukemic cells from unstimulated and mitogen-stimulated cultures revealed a consistent karyotype characterized by marker chromosomes and a decreased chromosome number, whereas chromosomal analysis of hair root cells yielded a normal karyotype. A uniform expression of T-cell antigens measured on single leukemic cells by quantitative microphotometric immunoautoradiography correlated with the cytogenetic findings which are compatible with a descent from one progenitor cell.
| Reference Key |
thiel1970blutevidence
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| Authors | E. Thiel;M. Bauchinger;H. Rodt;D. Huhn;H. Theml;S. Thierfelder;E. Thiel;M. Bauchinger;H. Rodt;D. Huhn;H. Theml;S. Thierfelder; |
| Journal | blut |
| Year | 1970 |
| DOI |
doi:10.1007/BF00996689
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| URL | |
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