Microarray analysis identifies candidate genes for key roles in coral development

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ID: 113896
2008
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Abstract
Anthozoan cnidarians are amongst the simplest animals at the tissue level of organization, but are surprisingly complex and vertebrate-like in terms of gene repertoire. As major components of tropical reef ecosystems, the stony corals are anthozoans of particular ecological significance. To better understand the molecular bases of both cnidarian development in general and coral-specific processes such as skeletogenesis and symbiont acquisition, microarray analysis was carried out through the period of early development – when skeletogenesis is initiated, and symbionts are first acquired. Of 5081 unique peptide coding genes, 1084 were differentially expressed (P ≤ 0.05) in comparisons between four different stages of coral development, spanning key developmental transitions. Genes of likely relevance to the processes of settlement, metamorphosis, calcification and interaction with symbionts were characterised further and their spatial expression patterns investigated using whole-mount in situ hybridization. This study is the first large-scale investigation of developmental gene expression for any cnidarian, and has provided candidate genes for key roles in many aspects of coral biology, including calcification, metamorphosis and symbiont uptake. One surprising finding is that some of these genes have clear counterparts in higher animals but are not present in the closely-related sea anemone Nematostella. Secondly, coral-specific processes (i.e. traits which distinguish corals from their close relatives) may be analogous to similar processes in distantly related organisms. This first large-scale application of microarray analysis demonstrates the potential of this approach for investigating many aspects of coral biology, including the effects of stress and disease.
Reference Key
grasso2008bmcmicroarray Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lauretta C Grasso;John Maindonald;Stephen Rudd;David C Hayward;Robert Saint;David J Miller;Eldon E Ball;Lauretta C Grasso;John Maindonald;Stephen Rudd;David C Hayward;Robert Saint;David J Miller;Eldon E Ball;
Journal BMC genomics
Year 2008
DOI
doi:10.1186/1471-2164-9-540
URL
http://dx.doi.org/10.1186%2F1471-2164-9-540
Keywords
Proteomics life sciences microarrays general animal genetics and genomics microbial genetics and genomics plant genetics and genomics National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't amino acid sequence DNA Molecular Sequence Data Expressed Sequence Tags complementary / genetics anthozoa / genetics* gene expression profiling* biological / genetics calcification cluster analysis pmid:19014561 pmc2629781 doi:10.1186/1471-2164-9-540 lauretta c grasso john maindonald eldon e ball anthozoa / growth & development physiologic / genetics metamorphosis oligonucleotide array sequence analysis* symbiosis / genetics

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