408 CONTINUOUS SUBCUTANEOUS INFUSION OF GROWTH HORMONE (CSIGH) IN GROWTH HORMONE DEFICIENCY: FEASIBILITY AND SHORT TERM METABOLIC EFFECTS
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ID: 113873
1970
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Abstract
In contrast to the sustained acceleration of growth observed in pituitary hypersecretion of GH, full catch-up growth is rarely attained in GH deficiency with conventional GH Rx (0.1 U/kg IM 3x/wk). Since circulating GH levels are very low for all but 24-30 hr per wk during conventional Rx, we examined the feasibility and short term metabolic effects of CSIGH using a small infusion pump. Fasting levels of glucose (G), insulin (I), free fatty acids (FFA) and oral glucose tolerance were determined in 5 previously untreated deficient children before and after 85 hrs of CSIGH (dose 2.1 μU/kg/hr ∼ 0.3 U/kg/wk). CSIGH maintained serum GH levels at 3-9 ng/ml during the infusion. As shown in the table, CSIGH produced a modest increase in fasting (0 min) G and I. Furthermore, glucose tolerance was impaired despite 2-fold higher I levels (*p
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| Reference Key |
gertner1970pediatric408
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|---|---|
| Authors | J Gertner;S Page;W Tamborlane;J Gertner;S Page;W Tamborlane; |
| Journal | Pediatric research |
| Year | 1970 |
| DOI |
doi:10.1203/00006450-198104001-00419
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