Dendritic Cell Anergy Results from Endotoxemia in Severe Malnutrition

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ID: 113751
2009
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Abstract
Malnutrition predicts an increased risk of morbidity and mortality from infection. Defects in cell-mediated immunity, such as thymic atrophy, impaired cutaneous tuberculin responses, and reduced T cell mitogenesis in vitro, are well characterized. There has been no convincing mechanism proposed for these T cell defects. However, as T cell responses rely on signals received from APCs, this study evaluates dendritic cell (DC) function in children with severe malnutrition. Repeated sampling of peripheral blood from 81 severely malnourished children at the University Teaching Hospital, Lusaka, Zambia, demonstrated for the first time a defect in DC numbers in children with malnutrition (28 per microliter) and a recovery in cell number (48 per microliter; p < 0.01) with standard treatment. We describe normal DC maturation in the majority of malnourished children. However, in 17% of our study patients, in association with endotoxemia we describe the novel finding of DC maturation failure (down-regulation rather than up-regulation of HLA-DR). There was a strong correlation between the strength of HLA-DR up or down-regulation and the generation of IL-10 ( r = −0.481; p = 0.003). These “anergic” DCs failed to support T cell proliferation. Defects in DC number and the immunosuppressive phenotype of DCs from severely malnourished children with endotoxemia provide a rational basis for the anergy found in severe malnutrition.
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hughes2009thedendritic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Stephen Miles Hughes;Beatrice Amadi;Mwiya Mwiya;Hope Nkamba;Andrew Tomkins;David Goldblatt;Stephen Miles Hughes;Beatrice Amadi;Mwiya Mwiya;Hope Nkamba;Andrew Tomkins;David Goldblatt;
Journal the journal of immunology
Year 2009
DOI
10.4049/jimmunol.0803518
URL
https://dx.doi.org/10.4049%2Fjimmunol.0803518
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male Child Infant Comparative Study preschool Cells Cultured severity of illness index Cohort Studies interleukin-12 / deficiency hiv infections / immunology malnutrition / immunology* dendritic cells / immunology* pmid:19625645 doi:10.4049/jimmunol.0803518 stephen miles hughes beatrice amadi david goldblatt coculture techniques dendritic cells / metabolism dendritic cells / pathology* down-regulation / immunology endotoxemia / immunology* endotoxemia / metabolism endotoxemia / pathology* hiv infections / metabolism hiv infections / pathology hla-dr antigens / metabolism interleukin-10 / metabolism malnutrition / metabolism malnutrition / pathology* up-regulation / immunology

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