Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes
Clicks: 261
ID: 113744
2019
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Abstract
Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm. We report cryo-EM structures of core and complete vRNAP enzymes from Vaccinia virus at 2.8 Å resolution. The vRNAP core enzyme resembles eukaryotic RNA polymerase II (P …
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| Reference Key |
c2019cellstructural
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|---|---|
| Authors | Grimm C;Hillen HS;Bedenk K;Bartuli J;Neyer S;Zhang Q;Hüttenhofer A;Erlacher M;Dienemann C;Schlosser A;Urlaub H;Böttcher B;Szalay AA;Cramer P;Fischer U;; |
| Journal | Cell |
| Year | 2019 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
vaccinia virus / genetics
pmid:31835032
doi:10.1016/j.cell.2019.11.024
clemens grimm
hauke s hillen
utz fischer
cryoelectron microscopy
dna-directed rna polymerases / chemistry*
multienzyme complexes / chemistry
multienzyme complexes / ultrastructure
single molecule imaging
transcription factors / chemistry*
vaccinia virus / metabolism
vaccinia virus / ultrastructure*
viral proteins / chemistry*
|
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