Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes

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ID: 113744
2019
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Abstract
Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm. We report cryo-EM structures of core and complete vRNAP enzymes from Vaccinia virus at 2.8 Å resolution. The vRNAP core enzyme resembles eukaryotic RNA polymerase II (P …
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Authors Grimm C;Hillen HS;Bedenk K;Bartuli J;Neyer S;Zhang Q;Hüttenhofer A;Erlacher M;Dienemann C;Schlosser A;Urlaub H;Böttcher B;Szalay AA;Cramer P;Fischer U;;
Journal Cell
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/31835032/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't vaccinia virus / genetics pmid:31835032 doi:10.1016/j.cell.2019.11.024 clemens grimm hauke s hillen utz fischer cryoelectron microscopy dna-directed rna polymerases / chemistry* multienzyme complexes / chemistry multienzyme complexes / ultrastructure single molecule imaging transcription factors / chemistry* vaccinia virus / metabolism vaccinia virus / ultrastructure* viral proteins / chemistry*

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