BHT blocks NF-kappaB activation and ethanol-induced brain damage

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ID: 113407
2006
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Abstract
Binge-induced brain damage and activation of NF-kappaB-DNA binding are blocked by BHT. These studies support a neuroinflammatory mechanism of binge ethanol-induced brain damage.
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Authors Crews F, Nixon K, Kim D, Joseph J, Shukitt-Hale B, Qin L, Zou J
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Journal Alcoholism, clinical and experimental research
Year 2006
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/17067360
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support male N.I.H. Extramural Ethanol / toxicity* Rats Sprague-Dawley dentate gyrus / pathology immunohistochemistry stem cells / drug effects antioxidants / pharmacology* central nervous system depressants / toxicity* pmid:17067360 doi:10.1111/j.1530-0277.2006.00239.x fulton crews kimberly nixon jian zou biotransformation / drug effects brain damage chronic / chemically induced* chronic / prevention & control* butylated hydroxytoluene / pharmacology* central nervous system depressants / antagonists & inhibitors cyclooxygenase 2 / metabolism electrophoretic mobility shift assay ethanol / antagonists & inhibitors nf-kappa b / metabolism* nerve degeneration / chemically induced nerve degeneration / psychology rna / biosynthesis rna / isolation & purification reverse transcriptase polymerase chain reaction silver staining stem cells / pathology

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