Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization

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ID: 113352
1990
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Abstract
Formalin-inactivated (FI) RSV, purified F glycoprotein in alum, and RSV infection (intranasal) were compared for their immunogenicity, efficacy, and ability to enhance pulmonary histopathology during RSV infection 3 and 6 months following immunization by the intramuscular route. Purified influenza v …
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Authors Murphy BR;Sotnikov AV;Lawrence LA;Banks SM;Prince GA;;
Journal Vaccine
Year 1990
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/2251875
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine Comparative Study Antigens respiratory syncytial viruses / immunology* sigmodontinae time factors respiratory syncytial viruses / isolation & purification vaccines bronchi / pathology pulmonary alveoli / pathology enzyme-linked immunosorbent assay b r murphy g a prince hn protein* viral envelope proteins viral proteins* respirovirus infections / immunology* viral / immunology* pmid:2251875 doi:10.1016/0264-410x(90)90253-i a v sotnikov formaldehyde / pharmacology inactivated / immunology* viral vaccines / isolation & purification

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