Cystathionase: A potential cytoplasmic marker of hematopoietic differentiation

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ID: 113314
1970
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Abstract
Cysteine auxotrophy and absence of cystathionase (CSE) has been associated with certain human and rodent leukemic cell lines. To determine whether this state was a marker of malignant transformation or of cellular differentiation, CSE content was measured in 16 well characterized human leukemia-lymphoma cell lines. Enzyme was easily detected in several lines but its level did not correlate with a proposed scheme of differentiation based on cell-surface markers. However, the apparent absence of enzyme in human bone marrow CFU-C determined by growth experiments suggests reduced levels of CSE may be a marker of cytoplasmic immaturity.
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link1970blutcystathionase: Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors D. Link;C. Drebing;L. M. Glode;D. Link;C. Drebing;L. M. Glode;
Journal blut
Year 1970
DOI
doi:10.1007/BF00321048
URL
https://link.springer.com/article/10.1007/BF00321048
Keywords
oncology hematology

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