In Vitro Effects of Bisphenol A and Tetrabromobisphenol A on Cell Viability and Reproduction-Related Gene Expression in Pituitaries from Sexually Maturing Atlantic Cod (Gadus morhua L.)

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ID: 113235
2019
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Abstract
Bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) are widely used industrial chemicals, ubiquitously present in the environment. While BPA is a well-known endocrine disruptor and able to affect all levels of the teleost reproductive axis, information regarding TBBPA on this subject is very limited. Using primary cultures from Atlantic cod (Gadus morhua), the present study was aimed at investigating potential direct effects of acute (72 h) BPA and TBBPA exposure on cell viability and the expression of reproductive-relevant genes in the pituitary. The results revealed that both bisphenols stimulate cell viability in terms of metabolic activity and membrane integrity at environmentally relevant concentrations. BPA had no direct effects on gonadotropin gene expression, but enhanced the expression of gonadotropin-releasing hormone (GnRH) receptor 2a, the main gonadotropin modulator in Atlantic cod. In contrast, TBBPA increased gonadotropin transcript levels but had no effect on GnRH receptor mRNA. In conclusion, both anthropogenic compounds display endocrine disruptive properties and are able to directly interfere with gene expression related to reproductive function in cod pituitary cells at environmentally relevant concentrations in vitro.
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krogh2019fishesin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kristine von Krogh;Erik Ropstad;Rasoul Nourizadeh-Lillabadi;Trude Marie Haug;Finn-Arne Weltzien;von Krogh, Kristine;Ropstad, Erik;Nourizadeh-Lillabadi, Rasoul;Haug, Trude Marie;Weltzien, Finn-Arne;
Journal fishes
Year 2019
DOI
10.3390/fishes4030048
URL
https://www.mdpi.com/2410-3888/4/3/48
Keywords
reproduction endocrine disruption gonadotropin gnrh receptor teleost

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