Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant

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ID: 113053
2003
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Abstract
A major pathogenic mechanism of chronic alcoholism involves oxidative burden to liver and other cell types. We show that adult neurogenesis within the dentate gyrus of the hippocampus is selectively impaired in a rat model of alcoholism, and that it can be completely prevented by the antioxidant ebs …
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Authors Herrera DG;Yague AG;Johnsen-Soriano S;Bosch-Morell F;Collado-Morente L;Muriach M;Romero FJ;Garcia-Verdugo JM;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2003
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/12792022
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Rats Sprague-Dawley microscopy time factors electron neurons / drug effects hippocampus / drug effects* antioxidants / pharmacology* pmid:12792022 pmc164688 doi:10.1073/pnas.1230907100 daniel g herrera almudena g yague j manuel garcia-verdugo alcoholism* antimetabolites / pharmacology azoles / pharmacology bromodeoxyuridine / pharmacology cell division / drug effects cell survival / drug effects ethanol / adverse effects* hippocampus / pathology neurons / pathology neuroprotective agents / pharmacology nitrogen / metabolism olfactory bulb / drug effects organoselenium compounds / pharmacology oxidative stress

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