Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer

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ID: 112881
2020
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Abstract
An abnormality in hedgehog (Hh) signaling has been implicated in the progression of prostate cancer (PCa) to a more aggressive and therapy-resistant disease. Our assessments of human PCa tissues have shown an overexpression of the Hh pathway molecules, glioma-associated oncogene homolog 1 (GLI-1), and sonic hedgehog (SHH). The effect of the natural compound thymoquinone (TQ) in controlling the expression of Hh signaling molecules in PCa was investigated in this study. We generated planetary ball-milled nanoparticles (PBM-NPs) made with a natural polysaccharide, containing TQ, and coated with an RNA aptamer, A10, which binds to prostate-specific membrane antigen (PSMA). We prepared docetaxel-resistant C4-2B-R and LNCaP-R cells with a high expression of Hh, showing the integration of drug resistance and Hh signaling. Compared to free TQ, A10-TQ-PBM-NPs were more effective in controlling the Hh pathway. Our findings reveal an effective treatment strategy to inhibit the Hh signaling pathway, thereby suppressing PCa progression.
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singh2020cellsselective Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Santosh Kumar Singh;Jennifer B. Gordetsky;Sejong Bae;Edward P. Acosta;James W. Lillard;Rajesh Singh;Singh, Santosh Kumar;Gordetsky, Jennifer B.;Bae, Sejong;Acosta, Edward P.;Lillard, James W.;Singh, Rajesh;
Journal Cells
Year 2020
DOI
10.3390/cells9091976
URL
https://www.mdpi.com/2073-4409/9/9/1976
Keywords
nanoparticles prostate cancer aptamer thymoquinone drug transporter

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