Estimation of salivary sialic acid in oral premalignancy and oral squamous cell carcinoma

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ID: 112660
2016
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Abstract
Aims: Oral cancer is the most life-threatening disease of oral tissues. In societies where the incidence of oral cancer is high, clinically recognizable premalignant lesions are particularly common. Diagnosing oral cancers at an early stage is critical in improving the survival rate and reducing the morbidity associated with the disease. Alterations in the sialic acid levels in cancer patients have stimulated interest in this sugar residue as a possible tumor marker. Settings and Design: The purpose of this study was to estimate the salivary sialic acid levels in patients with oral premalignancy and squamous cell carcinoma and to correlate it with their grades to develop a cost-effective and noninvasive diagnostic parameter. Materials and Methods: Unstimulated whole saliva was collected from the groups under study and subjected to biochemical analysis for determination of sialic acid levels. Statistical Analysis Used: The salivary sialic acid levels were correlated with the clinical stage and histological grade by one-way ANOVA (SPSS software version 15). Results: Salivary sialic acid was elevated in oral squamous cell carcinoma (OSCC) compared to oral premalignancy and control group. A statistically significant correlation was observed between the grades of squamous cell carcinoma, grades of dysplasia in premalignancy, and sialic acid level. Conclusion and Clinical Significance: Evaluation of salivary sialic acid levels in premalignant and malignant lesions can serve as a screening tool. The mortality and morbidity of OSCC can be reduced if the lesions are diagnosed in early precancerous states using such noninvasive diagnostic methods for screening and monitoring of the population.
Reference Key
chaudhari2016contemporaryestimation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chaudhari;Vishakha Chaudhari;GL Pradeep;Nilima Prakash;Aarti M Mahajan;
Journal contemporary clinical dentistry
Year 2016
DOI
0976-237X
URL
http://www.medknow.com/crt.asp?prn=7;aid=JCanResTher_2020_16_3_401_289974;rt=F;u=http://www.contempclindent.org/text.asp?2016/7/4/451/194108
Keywords
Online E-Journal full-text electronic free access open access oral squamous cell carcinoma contemporary clinical dentistry online submissionleukoplakia saliva sialic acid National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine pmid:27994410 pmc5141657 doi:10.4103/0976-237x.194108 vishakha chaudhari g l pradeep aarti m mahajan

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