Nod-like receptor protein 3 inflammasome in head-and-neck cancer

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ID: 112587
2020
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Abstract
Activation of inflammasomes has a decisive role in host defense mechanism against pathogens and other intracellular risk factors, but recently, it has been revealed that they play a significant role in the pathogenesis of several diseases, including cancer. Nod-like receptor protein 3 (NLRP3) inflammasome, the best-studied inflammasome, has contrasting roles in cancer development and progressions. In head-and-neck cancers, the upregulated level of NLRP3 promotes tumor progression. The main objective of this review is to provide current knowledge on the involvement of NLRP3 inflammasome in head-and-neck cancers. Deeper understanding of the biology of this dynamic protein complex provides new scope for the development of more effective anticancer therapies.
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sheeja2020journalnod-like Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sheeja;K Sheeja;S Lakshmi;
Journal journal of cancer research and therapeutics
Year 2020
DOI
0973-1482
URL
http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=3;spage=405;epage=409;aulast=Sheeja;type=3
Keywords
inflammation Online E-Journal full-text electronic free access open access Journal of Cancer Research and Therapeutics online submissionhead-and-neck cancer nrp3 inflammasome pattern recognition receptors

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